Spravato is a prescription nasal spray containing esketamine, a compound derived from ketamine. It is used alongside an oral antidepressant to address certain forms of depression that have not responded to other treatments. Esketamine works differently from most antidepressants; instead of targeting serotonin or norepinephrine, it acts on the brain’s glutamate system. The glutamate system plays a part in mood regulation and the formation of neural connections. Here’s more information on Spravato treatment and how the medication affects the body:
Managing Treatment-resistant Depression
Treatment-resistant depression is a form of major depressive disorder that doesn’t improve after trying two or more standard antidepressants at adequate doses and durations. A person may follow their prescribed plan closely, yet still notice little change in their symptoms. This condition can affect many areas of daily life. Persistent low mood, fatigue, and difficulty concentrating can interfere with work, relationships, and routine tasks.
Sleep patterns and appetite may shift, and many people withdraw from activities they once enjoyed. When earlier medications fail to bring relief, the search for an effective option can be discouraging. This ongoing struggle often makes each new attempt more challenging than the last for many people with treatment-resistant depression. After trying different medications and therapy options for mental health support, a neurologist may discuss Spravato treatment for some individuals.
Trying Medication Management
To determine candidacy for esketamine nasal spray treatments, a healthcare provider reviews a patient’s history, current symptoms, and previous treatments. Before starting, providers also assess factors such as blood pressure history and other medical conditions to determine whether the treatment is appropriate. Esketamine is not typically the first treatment choice for depression. This medication is prescribed for adults with treatment-resistant depression and, in some cases, for people with depressive disorders who have acute suicidal thoughts or behavior. Spravato is always used in combination with an oral antidepressant rather than on its own.
Utilizing Spravato Sessions
Spravato sessions take place in a certified healthcare setting under professional supervision, often from a neurologist. This means patients cannot take the medication at home. Spravato treatments are self-administered, but they occur in-office and are overseen by a medical provider.
After taking the spray, patients remain at the facility for at least two hours. During this period, a provider checks blood pressure before and after the dose, since esketamine can temporarily increase it. Staff also watch for effects such as dizziness, drowsiness, or detachment from one’s surroundings.
Patients can expect to sit in a quiet space during the observation window after the spray. Because the medication may affect alertness and coordination, individuals are advised not to drive or operate machinery until the following day after a restful sleep. Arranging transportation home in advance is standard practice. Session frequency often begins with twice-weekly visits and may adjust over time based on how a person responds. Providers document each visit to track progress and any effects.
Get Spravato Treatment for Your Depression
Spravato treatment offers a supervised, structured approach for adults whose depression has not responded to other medications. Each session includes monitoring to support timely care and verify individual safety. This level of oversight allows your providers to track your response and respond promptly to any adverse effects. If standard antidepressants have not brought the results you hoped for, contact a neurology practice that offers Spravato. A medical specialist can review your history, explain what each session involves, and outline the monitoring process in detail.
